Framing hyperneuroplasticity through epigenetics grounds this construct in biology and emphasizes both its risks and its extraordinary potential.

The DecodeME study marks a turning point. It acts as a compass pointing us to a terrain where ME/CFS is genetic, biological, and systemic, rather than irrational or hyperbolic. Hyperneuroplasticity tells us that this terrain is shared with those navigating MCAS, EDS, autism, ADHD, trauma, giftedness, and beyond.

Taken together, hyperneuroplasticity, the blood–brain barrier, EDS, MCAS, dysautonomia, and FND form a constellation of overlapping expressions of a body and brain that are open, sensitive, and dynamic. This reframing points toward interventions that aim to stabilize barriers, modulate immune activity, regulate autonomic flow, and most importantly, harness hyperneuroplasticity constructively through learning, creativity, and self-directed adaptation.