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The Neural Architecture of Transformation: Bridging Dąbrowski's Theory of Positive Disintegration and Hyperneuroplasticity
Dąbrowski’s Theory of Positive Disintegration anticipated what neuroscience now begins to affirm: certain nervous systems are built for transformation. Hyperneuroplasticity may provide the biological foundation for developmental potential, with the third factor as its governing mechanism and multilevelness as its structural expression.

Dr. Patty Gently
4 days ago9 min read


Entangled Autopoiesis Meets HNP: Why “Therapy” Works as a System
the goal is to co-create conditions where the system’s own intelligence can reorganize into new forms of stability and meaning

Dr. Patty Gently
Oct 58 min read


Paraneoplastic Disorders as an Edge Case for Hyperneuroplastic Systems
A striking medical parallel that illustrates this duality at an extreme of HNP is found in paraneoplastic disorders. I am actively collecting data on possible correlations between HNP neurodivergence and paraneoplastic disorders, an exploratory effort that remains preliminary but helps inform why I am attentive to this edge case.

Dr. Patty Gently
Oct 13 min read


Dyslexia, ADHD, Autism, and Hyperneuroplasticity: What a New Genetics Paper Adds
So imagine when I saw a cheesy Facebook post about a supposed 2025 genetics study that modeled how the DNA signals for dyslexia relate to other conditions and found that dyslexia aligns most closely with ADHD on a shared, attention-and-learning genetic pattern. Whoa. Too good to be true? Not when it's believable and supports a framework I’ve worked to develop.

Dr. Patty Gently
Sep 299 min read


Hyperneuroplasticity Across the Lifespan
Looking across the lifespan, hyperneuroplasticity emerges as a systemic orientation that permeates every stage of development, rather than a temporary trait to be gained or lost.

Dr. Patty Gently
Sep 158 min read


Neuroplasticity and Hyperplasticity vs. Hyperneuroplasticity
...HNP provides a useful umbrella for grouping certain forms of neurodivergence. Profiles such as autism, ADHD, giftedness, and trauma-shaped neurodivergence often share systemic hyperresponsiveness: accelerated learning, fluid identity shifts, sensory amplification, and greater susceptibility to both brilliance and destabilization. Seen through the lens of hyperneuroplasticity, these are all variations of a shared underlying orientation toward intensified plastic responsiven

Dr. Patty Gently
Sep 132 min read


Hyperneuroplasticity, Nitric Oxide, and Dynamic Brain-Body States
Bringing all these seemingly random threads of dynamic brain states, nitric oxide, and neurodivergence together highlights how hyperneuroplasticity involves the intimate coupling of brain and body.

Dr. Patty Gently
Sep 129 min read


The Hyperneuroplastic Octopus: Master of Neural Adaptation
For humans navigating giftedness, neurodivergence, or trauma recovery, the octopus serves as both metaphor and scientific model. It reminds us of our capacity for deep, systemic change and calls us to radically accept a fluidity that can be both barrier and brilliance.

Dr. Patty Gently
Sep 118 min read


Dynamic Systems, Process Metaphysics, and Hyperneuroplasticity: Stability Through Flux
Epigenetics illustrates how coherence at the cellular level is achieved through regulatory processes that are themselves mutable. Process metaphysics explains this at the level of being, while hyperneuroplasticity captures it in the lived experience of certain neurobiological profiles. Whether at the scale of molecules, neural networks, or whole organisms, stability arises by transforming with change rather than resisting it.

Dr. Patty Gently
Sep 39 min read


Hyperneuroplasticity in Action: DecodeME as Case Study
The DecodeME study marks a turning point. It acts as a compass pointing us to a terrain where ME/CFS is genetic, biological, and systemic, rather than irrational or hyperbolic. Hyperneuroplasticity tells us that this terrain is shared with those navigating MCAS, EDS, autism, ADHD, trauma, giftedness, and beyond.

Dr. Patty Gently
Aug 288 min read


The Shared Terrain of Hyperneuroplasticity, the Blood-Brain Barrier, and Functional Neurological Disorder (HNP, BBB, EDS, MCAS, POTS, and FND? WTF!!??)
Taken together, hyperneuroplasticity, the blood–brain barrier, EDS, MCAS, dysautonomia, and FND form a constellation of overlapping expressions of a body and brain that are open, sensitive, and dynamic. This reframing points toward interventions that aim to stabilize barriers, modulate immune activity, regulate autonomic flow, and most importantly, harness hyperneuroplasticity constructively through learning, creativity, and self-directed adaptation.

Dr. Patty Gently
Aug 279 min read


Hyperneuroplasticity as the Umbrella Neurodivergence for Deep Neural Adaptation
For years, we've been handed diagnostic fragments. Each label attempts to describe a set of traits, challenges, or neurological styles. Yet beneath the variation, there is a shared thread running through many of these lived experiences, one that rarely gets named directly: a nervous system that adapts quickly, deeply, and often at great cost.

Dr. Patty Gently
Jul 99 min read
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